Van Herck MA et al., 2017 Denk H et al., 2019 Ibrahim SH et al., 2016 Mann JP et al., 2016 Hansen HH et al., 2017 Bertola A, 2018 Trak-Smayra V et al., 2011 Wortham M et al., 2008 Van Herck MA et al., 2017 Denk H et al., 2019 Lau JK et al., 2017 Mann JP et al., 2016 Hansen HH et al., 2017 Bertola A, 2018 Kristiansen MN et al., 2016 Sahai A et al., 2004 Sun G et al., 2019 Boland ML et al., 2018 Mice fed specialized diets display a number of key NASH phenotypes, however, obesogenic models typically have incomplete penetrance and require a significant amount of time for induction.
♼57BL/6J mice are frequently used in NASH research due to their intrinsic predilection to metabolic syndrome and an intact leptin pathway. In contrast to ob/ob mice, db/db mice fed high calorie and MCD diets often develop moderate to severe liver fibrosis.Leptin-resistant db/db mice exhibit similar metabolic features to ob/ob mice, but have normal to elevated levels of leptin.Ob/ob mice fed obesogenic and MCD diets exhibit several key NASH features including steatosis and hepatocellular ballooning, but rarely develop significant fibrosis.Leptin-deficient ob/ob mice have a genetic predisposition to hyperphagy and obesity.Progression of NASH can be induced by feeding with an obesogenic diet, resulting in steatosis, inflammation, hepatocellular ballooning, and fibrosis.MS-NASH is a polygenic mouse model with an intact leptin pathway that develops many of the features associated with metabolic syndrome.High Fat, High Cholesterol, and High Fructose Relative Time to Induction (Scale from 1 to 5)
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